منابع مشابه
T cell traffic signals
In 1990, Charles Mackay and colleagues combined classical physiology with modern molecular biology to provide the first concrete evidence that naive and memory T cells follow distinct migratory routes out of the bloodstream--a discovery that helped invigorate the field of lymphocyte homing.
متن کاملDCs redirect T cell traffic
Dendritic cells (DCs) are the master regulators of T cell recirculation, according to a study by Mora et al. on page 303. Memory T cells—thought to be programmed to return to the location in which they first encountered antigen—can be rerouted by an encounter with a DC from another location. Previous studies have shown that memory T cells express a characteristic array of adhesion molecules and...
متن کاملCD47 signals T cell death.
Activation-induced death of T cells regulates immune responses and is considered to involve apoptosis induced by ligation of Fas and TNF receptors. The role of other receptors in signaling T cell death is less clear. In this study we demonstrate that activation of specific epitopes on the Ig variable domain of CD47 rapidly induces apoptosis of T cells. A new mAb, Ad22, to this site induces apop...
متن کاملCD99 signals caspase-independent T cell death.
Death signaling by Fas and TNF receptors plays a major role in the control of activated mature T cells. However, the nature of the death receptors, which may be used by the immune system to control T cells that have not acquired susceptibility to Fas ligand or TNF, is not established. In this study, we demonstrate that engagement of distinct epitopes on CD99 rapidly induces T cell death by a no...
متن کاملAdaptive Traffic Signals
Adaptive traffic signals have had a checkered history in the U.S.A., and many professionals are unsure about whether the benefits justify the costs. The FHWA sponsored research into adaptive signals and several systems have now been developed to the stage where demonstration projects are underway (e.g., RHODES and OPAC). At the same time several adaptive systems (e.g., SCATS and SCOOT) have bee...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2005
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.2024fta